Conserved serines of transmembrane 5 in the dopamine D 1 receptor interact with non‐catechol D 1 ligands
نویسندگان
چکیده
منابع مشابه
BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION
Intraperitoneal (IP) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-ad...
متن کاملbupropion-induce d climbing throu gh d -1 and d-2 dopamine receptor activation
intraperitoneal (ip) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. the climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist sch 233<)0 or the 0-2 antagonist sulpiride. the α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adre...
متن کاملLigand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.
To refine further the structure-activity relationships of D(1) dopamine receptor agonists, we investigated the roles of three conserved serine residues [Ser198(5.42), Ser199(5.43), and Ser202(5.46)] in agonist binding and receptor activation. These transmembrane domain 5 (TM5) residues are believed to engage catechol ligands through polar interactions. We stably expressed wild-type or mutant (S...
متن کاملDopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro.
Dopamine and glutamate are key neurotransmitters involved in learning and memory mechanisms of the brain. These two neurotransmitter systems converge on nerve cells in the neostriatum. Dopamine modulation of activity-dependent plasticity at glutamatergic corticostriatal synapses has been proposed as a cellular mechanism for learning in the neostriatum. The present research investigated the role...
متن کاملEffects of dopamine D 1 and D 2 receptor antagonists on laryngeal 1 neurophysiology in the rat
Effects of dopamine D1 and D2 receptor antagonists on laryngeal 1 neurophysiology in the rat 2 Xin Feng, Victor M. Henriquez, Judith R. Walters, Christy L. Ludlow 3 1 Laryngeal and Speech Section, Medical Neurology Branch, National Institute of 4 Neurological Disorders and Stroke, Building 10, Room 5D38, 10 Center Drive MSC 5 1416, Bethesda, MD 20892-1416, USA 6 2 Neurophysiological Pharmacolog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.883.4